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What is GLP 1 & Does it Affect Weight & Cognition? SelfHacked Preconception use of GLP 1 and GLP 1 GIP receptor agonists for obesity treatment ScienceDirect The GLP 1 Handbook LBA Books Cardiovascular Actions and Clinical Outcomes With Glucagon Like Peptide 1 Receptor Agonists and Dipeptidyl Peptidase 4 Inhibitors Circulation How much can each antidiabetic drug drop HbA1C? Sulfonylurea: 12% GLP 1 agonist: 0.51.1% SGLT 2 inhibitor: 0.80.9% Metformin: ~1% Glitazone: 11.5% Insulin: up to Central glucagon like peptide 1 receptor activation inhibits Toll like receptor agonist induced inflammation: Cell Metabolism
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.7 ★★★★★
Based on 469 reviews
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Product Reviews
★★★★★ 4
These shoes make a great first impression, but beware of the stingy toe box.
Size: 13.5 Wide Big Kid, Color: Black/Orange
These shoes make a good first impression. They look sharp and appear to be well-made for running shoes. They also get bonus points for having actual laces instead of the common velco/fake laces combo. However, my son struggled to get them on at first due to limited room in the toe box. He has wide feet as well as high arches and the shoes were very snug across the top of his foot initially. Once he got them on, we determined that they were both wide enough (which is a rarity in itself) and the right size – just tight across the top. I actually had to remove the insoles to get them on his feet at first. After a few minutes I tried again with the insoles and he wore them around the house for a few hours, at which point the upper material had relaxed and/or the footbed had started to take on the shape of his foot, in effect creating more wiggle room. By then he didn't want to take them off, so they must have gotten more comfortable after that brief break-in period. If they were still too tight I'm sure he would have complained. I'll update the review if the shoes wear out prematurely or there is anything else noteworthy to report.
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Reviewed in the United States on August 15, 2024
★★★★★ 5
Awesome shoes
Size: 6 Wide Big Kid, Color: Black/Orange
Awesome shoes, great tread, comfortable!
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Reviewed in the United States on February 25, 2026
★★★★★ 5
Great sneaker!
Size: 11 Big Kid, Color: Navy/Teal/Coral
Great sneaker, my kids love them.
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Reviewed in the United States on February 23, 2026
★★★★★ 1
Sole separation
Size: 3 Big Kid, Color: Black/Orange, Size: 3 Big Kid, Color: Black/Orange
I really dont like to write reviews, let alone a negative one. Have had the shoe 1 month and the out sole on both shoes are peeling up. Normally we have had great success with saucony shoes for my boys. But this one we haven't had good luck. I have been super gluing the soles back down everything they peal up. Hopefully this is just a 1 off incident. Both side of one shoe and a large chunk of the heal on the other. You can see the glue marks and separation in pictures.
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Reviewed in the United States on September 17, 2025
★★★★★ 5
Will last!
Size: 5.5 Big Kid, Color: Black/Orange
Done wasting money on cheap shoes that fall apart! My grandson loved the colors and I like the durability. This is a great brand. Fits great and will last!
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Reviewed in the United States on August 20, 2025
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